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ACRP ACRP-CP Exam Syllabus Topics:

SectionWeightObjectives
Clinical Study Operations15%- Project management
  • 1. Vendor and stakeholder management
  • 2. Timeline and budget management
- Site management
  • 1. Site personnel training and delegation
  • 2. Study documentation and record keeping
Data Management and Informatics17%- Data quality control
  • 1. Data validation and cleaning
  • 2. Query management and resolution
- Data collection
  • 1. Electronic data capture systems
  • 2. Case report form design and completion
- Data reporting
  • 1. Database lock and data transfer
  • 2. Data integrity and security
Study Design and Conduct17%- Study implementation
  • 1. Site selection and activation
  • 2. Study monitoring and oversight
  • 3. Investigational product management
- Study planning
  • 1. Study population and eligibility criteria
  • 2. Sample size and statistical considerations
  • 3. Protocol development and amendments
Ethical and Participant Safety Considerations19%- Safety monitoring and reporting
  • 1. Adverse event identification and classification
  • 2. Safety information evaluation and communication
- Clinical care and management of research participants
  • 1. Standard of care vs protocol requirements
  • 2. Continuity of medical care
  • 3. Informed consent development and review
- Ethical principles
  • 1. Clinical equipoise and therapeutic misconception
  • 2. Human subject protections and privacy
Professionalism and Ethical Practice15%- Continuous improvement
  • 1. Professional development and education
  • 2. Quality assurance and process improvement
- Professional standards
  • 1. Confidentiality and conflict of interest
  • 2. Role responsibilities and boundaries
Regulatory and Compliance Requirements17%- International standards
  • 1. Declaration of Helsinki
- Compliance procedures
  • 1. Regulatory submissions and approvals
  • 2. Audits and inspections
- ICH Guidelines
  • 1. E6(R2)/E6(R3) Good Clinical Practice
  • 2. E8 General Considerations for Clinical Trials
  • 3. E2A Expedited Reporting
  • 4. E9 Statistical Principles
  • 5. E11 Pediatric Trials

ACRP Certified Professional Sample Questions:

1. A study sponsor approaches a facility about participating in their research study. The study sponsor requires use of social media as its sole method of recruitment. The site knows their institutional IRB/IEC does not approve of social media recruiting. How should the site respond?

A) Rely on the sponsor to notify the IRB/IEC.
B) Use a central IRB/IEC.
C) Recruit for the study without use of social media.
D) Decline the study.


2. Which of the following activities is the MOST efficient way of overseeing a CRO's management during a clinical trial?

A) Central monitoring of data fields by sponsor
B) Risk-based audits of CRO activities as delegated
C) Co-monitoring of CRO site visits
D) Pre-qualification assessment of CRO


3. A study is using an EDC system. After the data is entered into EDC, who is the next to review and conduct SDV of this data?

A) Sponsor
B) QA Department
C) Monitor
D) Data Manager


4. A representative from a regulatory authority shows up unannounced at a research site. After confirming their credentials, the representative requested to view the entire records, including identifiable information, from study XYZ that was closed out. Which of the following should the site personnel do next?

A) Allow access to the entire records.
B) Consult with the IRB/IEC first.
C) Redact subject identification for privacy protection.
D) Deny the request until the sponsor approves.


5. An interim analysis is conducted during a clinical trial. To review the results, the sponsor assigns:

A) Independent qualified individuals.
B) Investigators participating in the trial.
C) Regulatory authority expert advisors.
D) Executive board members.


Solutions:

Question # 1
Answer: D
Question # 2
Answer: B
Question # 3
Answer: C
Question # 4
Answer: A
Question # 5
Answer: A

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